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Genome Biol Evol

Title:		"Comparative Genomic Analysis of the Pheromone Receptor Class 1 Family (V1R) Reveals Extreme Complexity in Mouse Lemurs (Genus, Microcebus) and a Chromosomal Hotspot across Mammals"
Author(s):		Hunnicutt KE; Tiley GP; Williams RC; Larsen PA; Blanco MB; Rasoloarison RM; Campbell CR; Zhu K; Weisrock DW; Matsunami H; Yoder AD;
Address:		"Department of Biology, Duke University, Durham, North Carolina. Department of Biological Sciences, University of Denver, Denver, Colorado. Duke Lemur Center, Duke University, Durham, North Carolina. Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota. Behavioral Ecology and Sociobiology Unit, German Primate Centre, Gottingen, Germany. Departement de Biologie Animale, Universite d'Antananarivo, Madagascar, Antananarivo, Madagascar. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina. Department of Biology, University of Kentucky, Lexington, Kentucky. Department of Neurobiology, Duke Institute for Brain Sciences, Duke University Medical Center, Durham, North Carolina"
Journal Title:		Genome Biol Evol
Year:		2020
Volume:		12
Issue:		1
Page Number:		3562 - 3579
DOI:		10.1093/gbe/evz200
ISSN/ISBN:		1759-6653 (Electronic) 1759-6653 (Linking)
Abstract:		"Sensory gene families are of special interest for both what they can tell us about molecular evolution and what they imply as mediators of social communication. The vomeronasal type-1 receptors (V1Rs) have often been hypothesized as playing a fundamental role in driving or maintaining species boundaries given their likely function as mediators of intraspecific mate choice, particularly in nocturnal mammals. Here, we employ a comparative genomic approach for revealing patterns of V1R evolution within primates, with a special focus on the small-bodied nocturnal mouse and dwarf lemurs of Madagascar (genera Microcebus and Cheirogaleus, respectively). By doubling the existing genomic resources for strepsirrhine primates (i.e. the lemurs and lorises), we find that the highly speciose and morphologically cryptic mouse lemurs have experienced an elaborate proliferation of V1Rs that we argue is functionally related to their capacity for rapid lineage diversification. Contrary to a previous study that found equivalent degrees of V1R diversity in diurnal and nocturnal lemurs, our study finds a strong correlation between nocturnality and V1R elaboration, with nocturnal lemurs showing elaborate V1R repertoires and diurnal lemurs showing less diverse repertoires. Recognized subfamilies among V1Rs show unique signatures of diversifying positive selection, as might be expected if they have each evolved to respond to specific stimuli. Furthermore, a detailed syntenic comparison of mouse lemurs with mouse (genus Mus) and other mammalian outgroups shows that orthologous mammalian subfamilies, predicted to be of ancient origin, tend to cluster in a densely populated region across syntenic chromosomes that we refer to as a V1R 'hotspot.'"
Keywords:		"Animals Cheirogaleidae/*genetics Chromosomes, Mammalian DNA Copy Number Variations *Evolution, Molecular Genomics Mammals/genetics Mice *Multigene Family Receptors, Pheromone/*genetics Selection, Genetic Synteny Vomeronasal Organ Lemuriformes V1r gene fam;"
Notes:		"MedlineHunnicutt, Kelsie E Tiley, George P Williams, Rachel C Larsen, Peter A Blanco, Marina B Rasoloarison, Rodin M Campbell, C Ryan Zhu, Kevin Weisrock, David W Matsunami, Hiroaki Yoder, Anne D eng F31 DC017394/DC/NIDCD NIH HHS/ R01 DC014423/DC/NIDCD NIH HHS/ R01 DC016224/DC/NIDCD NIH HHS/ S10 OD018164/OD/NIH HHS/ Comparative Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England 2019/09/27 Genome Biol Evol. 2020 Jan 1; 12(1):3562-3579. doi: 10.1093/gbe/evz200"