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Eur Respir J
| Title: | A European Respiratory Society technical standard: exhaled biomarkers in lung disease |
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| Author(s): | Horvath I; Barnes PJ; Loukides S; Sterk PJ; Hogman M; Olin AC; Amann A; Antus B; Baraldi E; Bikov A; Boots AW; Bos LD; Brinkman P; Bucca C; Carpagnano GE; Corradi M; Cristescu S; de Jongste JC; Dinh-Xuan AT; Dompeling E; Fens N; Fowler S; Hohlfeld JM; Holz O; Jobsis Q; Van De Kant K; Knobel HH; Kostikas K; Lehtimaki L; Lundberg J; Montuschi P; Van Muylem A; Pennazza G; Reinhold P; Ricciardolo FLM; Rosias P; Santonico M; van der Schee MP; van Schooten FJ; Spanevello A; Tonia T; Vink TJ; |
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| Address: | "Dept of Pulmonology, National Koranyi Institute of Pulmonology, Budapest, Hungary ildiko.horvath@koranyi.hu. National Heart and Lung Institute, Imperial College London, Royal Brompton Hospital, London, UK. Pulmonary Dept, Nimits Hospital, Athens, Greece. Dept of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. Centre for Research & Development, Uppsala University/Gavleborg County Council, Gavle, Sweden. Occupational and Environmental Medicine, Sahlgrenska Academy and University Hospital, Goteborg, Sweden. Innsbruck Medical University, Innsbruck, Austria. Dept of Pathophysiology, National Koranyi Institute of Pulmonology, Budapest, Hungary. Pediatric Pneumonolgy, University of Padova, Padova, Italy. Dept of Pulmonology, Semmelweis University, Budapest, Hungary. Dept of Pharmacology and Toxicology, University of Maastricht, Maastricht, The Netherlands. Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Biomedical Sciences and Human Oncology, Universita' di Torino, Turin, Italy. Dept of Medical and Surgical Sciences, University of Foggia, Foggia, Italy. University of Parma, Parma, Italy. Dept of Molecular and Laser Physics, Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands. Dept of Pediatrics/Respiratory Medicine, Erasmus MC-Sophia Childrens' Hospital, Rotterdam, The Netherlands. Physiology, Paris Descartes University Cochin Hospital, Paris, France. Dept of Paediatrics/Family Medicine Research School CAPHRI, Maastricht University Medical Centre, Maastricht, The Netherlands. Respiratory Research Group, University of Manchester Wythenshawe Hospital, Manchester, UK. Clinical Airway Research, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, Germany. Medizinische Hochschule Hannover, Hannover, Germany. Department of Paediatric Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands. Philips Research, High Tech Campus 11, Eindhoven, The Netherlands. 2nd Respiratory Medicine Dept, University of Athens Medical School, Athens, Greece. Medical School, University of Tampere, Tampere, Finland. Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Pharmacology, Catholic University of the Sacred Heart, Rome, Italy. Hopital Erasme Cliniques Universitaires de Bruxelles, Bruxelles, Belgium. Faculty of Engineering, University Campus Bio-Medico, Rome, Italy. Institute of Molecular Pathogenesis, Friedrich Loeffler Institut, Jena, Germany. Clinic of Respiratory Disease, Dept of Clinical and Biological Sciences, University of Torino, Torino, Italy. Dept of Pediatrics, Maasland Hospital, Sittard, The Netherlands. Fondazione Salvatore Maugeri, Tradate, Italy. European Respiratory Society, Lausanne, Switzerland" |
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| Journal Title: | Eur Respir J |
| Year: | 2017 |
| Volume: | 20170426 |
| Issue: | 4 |
| Page Number: | - |
| DOI: | 10.1183/13993003.00965-2016 |
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| ISSN/ISBN: | 1399-3003 (Electronic) 0903-1936 (Linking) |
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| Abstract: | "Breath tests cover the fraction of nitric oxide in expired gas (F(eNO)), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for F(eNO), official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and F(eNO), new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management.Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members.Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised.Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice" |
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| Keywords: | "Biomarkers/analysis Breath Tests/*methods Europe Exhalation Humans Lung Diseases/*diagnosis/therapy Nitric Oxide/*analysis Societies, Medical Volatile Organic Compounds/*analysis;" |
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| Notes: | "MedlineHorvath, Ildiko Barnes, Peter J Loukides, Stelios Sterk, Peter J Hogman, Marieann Olin, Anna-Carin Amann, Anton Antus, Balazs Baraldi, Eugenio Bikov, Andras Boots, Agnes W Bos, Lieuwe D Brinkman, Paul Bucca, Caterina Carpagnano, Giovanna E Corradi, Massimo Cristescu, Simona de Jongste, Johan C Dinh-Xuan, Anh-Tuan Dompeling, Edward Fens, Niki Fowler, Stephen Hohlfeld, Jens M Holz, Olaf Jobsis, Quirijn Van De Kant, Kim Knobel, Hugo H Kostikas, Konstantinos Lehtimaki, Lauri Lundberg, Jon Montuschi, Paolo Van Muylem, Alain Pennazza, Giorgio Reinhold, Petra Ricciardolo, Fabio L M Rosias, Philippe Santonico, Marco van der Schee, Marc P van Schooten, Frederik-Jan Spanevello, Antonio Tonia, Thomy Vink, Teunis J eng Practice Guideline Research Support, Non-U.S. Gov't England 2017/04/28 Eur Respir J. 2017 Apr 26; 49(4):1600965. doi: 10.1183/13993003.00965-2016. Print 2017 Apr" |
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