| Title: | "Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction" |
| Author(s): | Hornung J; Noack H; Thomas M; Farger G; Nieratschker V; Freiherr J; Derntl B; |
| Address: | "Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany. Electronic address: jonas.hornung@med.uni-tuebingen.de. Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany; Lead Graduate School, University of Tubingen, Tubingen, Germany. Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany. Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany; Werner Reichardt Centre for Integrative Neuroscience, University of Tubingen, Tubingen, Germany. Diagnostic and Interventional Neuroradiology, Universitatsklinikum RWTH Aachen, Aachen, Germany; Fraunhofer Institute for Process Engineering and Packaging IVV, Freising, Germany. Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany; Werner Reichardt Centre for Integrative Neuroscience, University of Tubingen, Tubingen, Germany; Lead Graduate School, University of Tubingen, Tubingen, Germany" |
| DOI: | 10.1016/j.yhbeh.2017.12.003 |
| ISSN/ISBN: | 1095-6867 (Electronic) 0018-506X (Linking) |
| Abstract: | "The androgen derivative androstadienone (AND) is present in human sweat and may act as human chemosignal. Though effects of AND have been reported with respect to emotional and cognitive processes, results have been highly inconsistent. For this reason, it is likely that AND-action is dependent on modulatory factors. Here we wanted to specifically investigate the impact of genotypic variations of the AND-receptor OR7D4, as well as the influence of participant sex and concomitant hormonal fluctuations on AND-action during emotional interference processing, olfactory performance and mood assessments. To this end 80 healthy individuals (women taking oral contraceptives; naturally cycling women measured during the luteal phase and men) were tested twice on two consecutive days (AND vs. placebo exposure) with an emotional Stroop task. Also, olfactory performance and mood was assessed. Participants provided saliva samples to measure testosterone, progesterone and estradiol and a blood sample to assess genotypic variations of the AND-receptor OR7D4. We found a small task-dependent reduction of overall error rates under AND but no modulation of effects by genetic variation or group (female OC, female NC, male) with respect to olfactory performance and mood. Additional analyses with help of Bayesian statistics gave strong evidence in favor of specific null hypotheses suggesting that the action of AND was not modulated by either genotypic variations or sex of participants with respect to interference control (bias indices), olfactory self-reports and mood parameters. Additional effects of AND in connection with hormonal fluctuations are reported" |
| Keywords: | "Adolescent Adult *Affect/drug effects/physiology Androstadienes/*pharmacology Bayes Theorem Emotions/drug effects Estradiol/blood Female Gene-Environment Interaction Genotype Humans Luteal Phase/blood Male Progesterone/blood Psychological Tests Receptors, ;" |
| Notes: | "MedlineHornung, Jonas Noack, Hannes Thomas, Mara Farger, Gisbert Nieratschker, Vanessa Freiherr, Jessica Derntl, Birgit eng Randomized Controlled Trial Research Support, Non-U.S. Gov't 2017/12/17 Horm Behav. 2018 Feb; 98:45-54. doi: 10.1016/j.yhbeh.2017.12.003. Epub 2017 Dec 22" |
