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Curr Biol

Title:		Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans
Author(s):		Hong M; Ryu L; Ow MC; Kim J; Je AR; Chinta S; Huh YH; Lee KJ; Butcher RA; Choi H; Sengupta P; Hall SE; Kim K;
Address:		"Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, Republic of Korea. Department of Biology, Syracuse University, Syracuse, NY 13244, USA. Center for Electron Microscopy Research, Korea Basic Science Institute, Cheongju-si, Chungcheongbuk-do 28119, Republic of Korea. Department of Chemistry, University of Florida, Gainesville, FL 32611, USA. Korea Brain Research Institute, Daegu 41068, Republic of Korea. Robotics Engineering Department, DGIST, Daegu 42988, Republic of Korea. Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA. Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, Republic of Korea. Electronic address: khkim@dgist.ac.kr"
Journal Title:		Curr Biol
Year:		2017
Volume:		20171005
Issue:		20
Page Number:		3168 - 3177
DOI:		10.1016/j.cub.2017.08.068
ISSN/ISBN:		1879-0445 (Electronic) 0960-9822 (Print) 0960-9822 (Linking)
Abstract:		"Experiences during early development can influence neuronal functions and modulate adult behaviors [1, 2]. However, the molecular mechanisms underlying the long-term behavioral effects of these early experiences are not fully understood. The C. elegans ascr#3 (asc-DeltaC9; C9) pheromone triggers avoidance behavior in adult hermaphrodites [3-7]. Here, we show that hermaphrodites that are briefly exposed to ascr#3 immediately after birth exhibit increased ascr#3-specific avoidance as adults, indicating that ascr#3-experienced animals form a long-lasting memory or imprint of this early ascr#3 exposure [8]. ascr#3 imprinting is mediated by increased synaptic activity between the ascr#3-sensing ADL neurons and their post-synaptic SMB motor neuron partners via increased expression of the odr-2 glycosylated phosphatidylinositol (GPI)-linked signaling gene in the SMB neurons. Our study suggests that the memory for early ascr#3 experience is imprinted via alteration of activity of a single synaptic connection, which in turn shapes experience-dependent plasticity in adult ascr#3 responses"
Keywords:		Animals Avoidance Learning Caenorhabditis elegans/*physiology Hermaphroditic Organisms/physiology *Memory Pheromones/*physiology Sensory Receptor Cells/*physiology Signal Transduction GPI-anchored protein neuronal activity pheromone sensory imprinting syn;
Notes:		"MedlineHong, Myeongjin Ryu, Leesun Ow, Maria C Kim, Jinmahn Je, A Reum Chinta, Satya Huh, Yang Hoon Lee, Kea Joo Butcher, Rebecca A Choi, Hongsoo Sengupta, Piali Hall, Sarah E Kim, Kyuhyung eng K99 GM087533/GM/NIGMS NIH HHS/ P40 OD010440/OD/NIH HHS/ R00 GM087533/GM/NIGMS NIH HHS/ R15 GM111094/GM/NIGMS NIH HHS/ England 2017/10/11 Curr Biol. 2017 Oct 23; 27(20):3168-3177.e3. doi: 10.1016/j.cub.2017.08.068. Epub 2017 Oct 5"