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Sci Rep

Title:		Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans
Author(s):		Honda Y; Higashibata A; Matsunaga Y; Yonezawa Y; Kawano T; Higashitani A; Kuriyama K; Shimazu T; Tanaka M; Szewczyk NJ; Ishioka N; Honda S;
Address:		"Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan. yhonda@center.tmig.or.jp"
Journal Title:		Sci Rep
Year:		2012
Volume:		20120705
Issue:
Page Number:		487 -
DOI:		10.1038/srep00487
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues"
Keywords:		"Animals Animals, Genetically Modified Caenorhabditis elegans/genetics/*physiology Endocrine Cells/metabolism *Gene Expression Regulation Longevity/*genetics Male Models, Biological Mutation Neurons/metabolism Pheromones/metabolism RNA Interference Signal;"
Notes:		"MedlineHonda, Yoko Higashibata, Akira Matsunaga, Yohei Yonezawa, Yukiko Kawano, Tsuyoshi Higashitani, Atsushi Kuriyama, Kana Shimazu, Toru Tanaka, Masashi Szewczyk, Nathaniel J Ishioka, Noriaki Honda, Shuji eng MR/K00414X/1/MRC_/Medical Research Council/United Kingdom R01 AR054342/AR/NIAMS NIH HHS/ AR054342/AR/NIAMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England 2012/07/07 Sci Rep. 2012; 2:487. doi: 10.1038/srep00487. Epub 2012 Jul 5"