| Title: | "Eighty years after its discovery, Fleming's Penicillium strain discloses the secret of its sex" |
| Author(s): | Hoff B; Poggeler S; Kuck U; |
| Address: | "Ruhr-Universitat Bochum, Lehrstuhl fur Allgemeine und Molekulare Botanik, Universitatsstr. 150, 44780 Bochum, Germany" |
| ISSN/ISBN: | 1535-9786 (Electronic) 1535-9778 (Print) 1535-9786 (Linking) |
| Abstract: | "Eighty years ago, Alexander Fleming discovered antibacterial activity in the asexual mold Penicillium, and the strain he studied later was replaced by an overproducing isolate still used for penicillin production today. Using a heterologous PCR approach, we show that these strains are of opposite mating types and that both have retained transcriptionally expressed pheromone and pheromone receptor genes required for sexual reproduction. This discovery extends options for industrial strain improvement programs using conventional genetical approaches" |
| Keywords: | "Amino Acid Sequence Fungal Proteins/chemistry/genetics *Genes, Mating Type, Fungal Molecular Sequence Data Penicillium chrysogenum/genetics/*physiology Pheromones/genetics Receptors, Pheromone/genetics Sequence Alignment Transcription, Genetic;" |
| Notes: | "MedlineHoff, Birgit Poggeler, Stefanie Kuck, Ulrich eng Research Support, Non-U.S. Gov't 2008/01/29 Eukaryot Cell. 2008 Mar; 7(3):465-70. doi: 10.1128/EC.00430-07. Epub 2008 Jan 25" |
