| Title: | Chemical gradients and chemotropism in yeast |
| Address: | "Institute of Developmental Biology and Cancer, Universite de Nice-Sophia Antipolis-CNRS UMR6543, Centre de Biochimie, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France. arkowitz@unice.fr" |
| Journal Title: | Cold Spring Harb Perspect Biol |
| DOI: | 10.1101/cshperspect.a001958 |
| ISSN/ISBN: | 1943-0264 (Electronic) 1943-0264 (Linking) |
| Abstract: | "Chemical gradients of peptide mating pheromones are necessary for directional growth, which is critical for yeast mating. These gradients are generated by cell-type specific secretion or export and specific degradation in receiving cells. Spatial information is sensed by dedicated seven-transmembrane G-protein coupled receptors and yeast cells are able to detect extremely small differences in ligand concentration across their approximately 5-microm cell surface. Here, I will discuss our current knowledge of how cells detect and respond to such shallow chemical gradients and in particular what is known about the proteins that are involved in directional growth and the establishment of the polarity axis during yeast mating" |
| Keywords: | "Actins/metabolism Cell Polarity Cell Shape Chemotaxis Fungal Proteins/metabolism GTP-Binding Proteins/metabolism Genes, Fungal Green Fluorescent Proteins/metabolism Ligands Models, Biological Models, Genetic Pheromones/metabolism Receptors, G-Protein-Coup;" |
| Notes: | "MedlineArkowitz, Robert A eng Research Support, Non-U.S. Gov't Review 2010/01/13 Cold Spring Harb Perspect Biol. 2009 Aug; 1(2):a001958. doi: 10.1101/cshperspect.a001958" |
