| Title: | Appeasing Pheromones against Bovine Respiratory Complex and Modulation of Immune Transcript Expressions |
| Author(s): | Hervet C; Boullier J; Guiadeur M; Michel L; Brun-Lafleur L; Aupiais A; Zhu J; Mounaix B; Meurens F; Renois F; Assie S; |
| Address: | "BIOEPAR, INRAE, Oniris, 44307 Nantes, France. Institut de l'Elevage, 14310 Villers-Bocage, France. TERRENA Innovation, La Noelle, 20199 Ancenis, France. Institut de l'Elevage, 35652 Le Rheu, France. College of Veterinary Medicine, Comparative Medicine Research Institute, Yangzhou University, Yangzhou 225009, China. Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou 225009, China. Department of Veterinary Microbiology and Immunology, Western College of Veterinary Medicine, Saskatoon, SK S7N5E3, Canada" |
| ISSN/ISBN: | 2076-2615 (Print) 2076-2615 (Electronic) 2076-2615 (Linking) |
| Abstract: | "Bovine respiratory disease is still a major concern and has major economic impact. Another consequence of respiratory infections is the use of antimicrobial molecules to control bacterial pathogens. This can participate in the emergence and shedding of antimicrobial resistance that can threaten animal as well as human health. Appeasing pheromones with their capacity to reduce stress and thus their ability to preserve the functions of the immune system have been proposed to reduce the use of antimicrobial substances. In this study, we assessed the effect of appeasing pheromone administration on bovine health and performance during the fattening period. Zootechnical and health parameters and whole blood immune transcript expressions were measured over four weeks in bulls to determine the effect of the pheromone. We observed increased clinical signs on Day 8 (D8) and decreased clinical signs on D30 in bulls who received the pheromone and a higher expression of interleukin 8 transcripts in this group than in the control group on D8. Our results are overall in line with previous reports in livestock species. Further studies are needed to shed more light on the effect of appeasing pheromones and decipher their exact mechanisms of action" |
| Keywords: | appeasing pheromone average daily gain bovine immune response respiratory infections; |
| Notes: | "PubMed-not-MEDLINEHervet, Caroline Boullier, Justine Guiadeur, Marlene Michel, Lea Brun-Lafleur, Laure Aupiais, Anne Zhu, Jianzhong Mounaix, Beatrice Meurens, Francois Renois, Fanny Assie, Sebastien eng SANT'Innov project/For and on Regional Development' PSDR 4 Grand Ouest funded by INRAE and the Regions Bre-tagne, Normandie, Nouvelle Aquitaine and Pays de Loire as part of the SANT'Innov project/ PHEROVEAU/Plan EcoAntibio du Ministere de l'Agriculture et de l'Alimentation (France)/ Switzerland 2021/06/03 Animals (Basel). 2021 May 25; 11(6):1545. doi: 10.3390/ani11061545" |
