| Title: | Non-Invasive Monitoring of Inflammation in Inflammatory Bowel Disease Patients during Prolonged Exercise via Exhaled Breath Volatile Organic Compounds |
| Author(s): | Henderson B; Meurs J; Lamers CR; Batista GL; Materic D; Bertinetto CG; Bongers C; Holzinger R; Harren FJM; Jansen JJ; Hopman MTE; Cristescu SM; |
| Address: | "Department of Analytical Chemistry and Chemometrics, Institute for Molecules and Materials, Radboud University, 6525 AJ Nijmegen, The Netherlands. Division of Human Nutrition and Health, Wageningen University & Research, 6708 WE Wageningen, The Netherlands. Department of Gastroenterology and Hepatology, Hospital Gelderse Vallei, 6716 RP Ede, The Netherlands. Institute for Marine and Atmospheric Research, Utrecht University, 3584 CC Utrecht, The Netherlands. Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 EZ Nijmegen, The Netherlands" |
| ISSN/ISBN: | 2218-1989 (Print) 2218-1989 (Electronic) 2218-1989 (Linking) |
| Abstract: | "The aim of this study was to investigate volatile organic compounds (VOCs) in exhaled breath as possible non-invasive markers to monitor the inflammatory response in inflammatory bowel disease (IBD) patients as a result of repeated and prolonged moderate-intensity exercise. We included 18 IBD patients and 19 non-IBD individuals who each completed a 30, 40, or 50 km walking exercise over three consecutive days. Breath and blood samples were taken before the start of the exercise event and every day post-exercise to assess changes in the VOC profiles and cytokine concentrations. Proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) was used to measure exhaled breath VOCs. Multivariate analysis, particularly ANOVA-simultaneous component analysis (ASCA), was employed to extract relevant ions related to exercise and IBD. Prolonged exercise induces a similar response in breath butanoic acid and plasma cytokines for participants with or without IBD. Butanoic acid showed a significant correlation with the cytokine IL-6, indicating that butanoic acid could be a potential non-invasive marker for exercise-induced inflammation. The findings are relevant in monitoring personalized IBD management" |
| Keywords: | PTR-ToF-MS breath analysis butanoic acid exercise inflammatory bowel disease volatile organic compounds; |
| Notes: | "PubMed-not-MEDLINEHenderson, Ben Meurs, Joris Lamers, Carlijn R Batista, Guilherme Lopes Materic, Dusan Bertinetto, Carlo G Bongers, Coen C W G Holzinger, Rupert Harren, Frans J M Jansen, Jeroen J Hopman, Maria T E Cristescu, Simona M eng 674911/H2020 Marie Sklodowska-Curie Actions Innovative Training Network: Ion-Molecule Processes for Analytical Chemistry Technologies (IMPACT)/ SEP-210497548/H2020-SFS-2018-2020 Fact-based personalised nutrition for the young (NUTRISHIELD)/ 024.002.001/The Netherlands Earth System Science Centre (NESSC) research network/ 400.17.604/The Dutch Research Agenda (NWA) for Startimpuls 'Meten en Detecteren van Gezond Gedrag" / Switzerland 2022/03/25 Metabolites. 2022 Mar 3; 12(3):224. doi: 10.3390/metabo12030224" |
