| Title: | Endocrine disruptive actions of inhaled benzo(a)pyrene on ovarian function and fetal survival in fisher F-344 adult rats |
| Author(s): | Archibong AE; Ramesh A; Inyang F; Niaz MS; Hood DB; Kopsombut P; |
| Address: | "Department of Physiology, Meharry Medical College, Nashville, TN 37208, United States. aarchibong@mmc.edu" |
| DOI: | 10.1016/j.reprotox.2012.09.003 |
| ISSN/ISBN: | 1873-1708 (Electronic) 0890-6238 (Print) 0890-6238 (Linking) |
| Abstract: | "This study evaluated the effect of inhaled BaP on female reproductive function. Rats were exposed to 50, or 75 or 100 mug BaP/m(3), 4 h a day for 14 days via inhalation. Plasma E(2), P(4), LH and FSH concentrations were determined. Ovarian BaP metabolism and aryl hydrocarbon hydrolase (AHH) activity at proestrus were determined and fertility evaluations were conducted. Ovulation rate and number of pups/litter were reduced in rats exposed to 100 mug BaP/m(3) compared with other treatment and control groups. Plasma concentrations of E(2), and LH were significantly reduced at proestrus in BaP-exposed versus those of controls whereas those of P(4) were significantly reduced at diestrus I. The activity of AHH in ovarian and liver tissues and concentrations of BaP 7,8-diol and BaP 3,6-dione metabolites increased in an exposure concentration-dependent manner. These data suggest that exposure of rats to BaP prior to mating contributes to reduced ovarian function and fetal survival" |
| Keywords: | "Administration, Inhalation Animals Aryl Hydrocarbon Hydroxylases/metabolism Benzo(a)pyrene/*toxicity Carcinogens/*toxicity Endocrine Disruptors/*toxicity Estradiol Estrous Cycle/drug effects Female Fertility/drug effects Fetus/*drug effects Follicle Stimu;" |
| Notes: | "MedlineArchibong, Anthony E Ramesh, Aramandla Inyang, Frank Niaz, Mohammad S Hood, Darryl B Kopsombut, Prapaporn eng U54 HD044315/HD/NICHD NIH HHS/ R03 CA130112/CA/NCI NIH HHS/ R15 ES012168/ES/NIEHS NIH HHS/ U54 RR022762/RR/NCRR NIH HHS/ G12 RR003032/RR/NCRR NIH HHS/ S11 ES014156/ES/NIEHS NIH HHS/ U54 MD007593/MD/NIMHD NIH HHS/ U54 MD008149/MD/NIMHD NIH HHS/ U54 RR026140/RR/NCRR NIH HHS/ R01 HD020419/HD/NICHD NIH HHS/ R01 CA142845/CA/NCI NIH HHS/ 2012/10/13 Reprod Toxicol. 2012 Dec; 34(4):635-43. doi: 10.1016/j.reprotox.2012.09.003. Epub 2012 Oct 8" |
