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J Med Eng Technol

Title:		Evaluation of gut bacterial populations using an electronic e-nose and field asymmetric ion mobility spectrometry: further insights into 'fermentonomics'
Author(s):		Arasaradnam RP; Ouaret N; Thomas MG; Gold P; Quraishi MN; Nwokolo CU; Bardhan KD; Covington JA;
Address:		"Warwick Medical School, University of Warwick, UK. R. Arasaradnam@warwick.ac.uk"
Journal Title:		J Med Eng Technol
Year:		2012
Volume:		20120705
Issue:		7
Page Number:		333 - 337
DOI:		10.3109/03091902.2012.690015
ISSN/ISBN:		1464-522X (Electronic) 0309-1902 (Linking)
Abstract:		"The fermentation of undigested foods in the large bowel, by its resident bacteria, results in the production of several chemicals including volatile gases. Perturbance in gut bacteria is known to influence colonic and metabolic health, but to determine this requires prolonged culture (often unsuccessful) or expensive genomic sequencing. Clearly this is not practical for daily clinical practice. Previously, we have reported our insights into fermentonomics through the detection of volatile organic compounds (VOCs) in patients with gastrointestinal and metabolic diseases, using the electronic nose. In this paper we report on the changes in the fermentone produced by patients undergoing complete versus partial bowel cleansing. Using urine samples, preliminary results from 23 individuals receiving bowel cleansing indicate the ability of the electronic nose to distinguish between the partial and complete procedures. Moreover in a subset of individuals, we have been able to track evolving bacterial recolonization over time using the e-nose and field asymmetric ion mobility spectrometry (FAIMS). Such an approach has practical application in tracking bacterial dysbiosis following perturbation"
Keywords:		"Adult Aged Aged, 80 and over Bacteria/isolation & purification Carbon Dioxide/urine *Electronic Nose Female Humans Hydrogen Sulfide/urine Intestine, Large/*microbiology Male Middle Aged Nitric Oxide/urine Spectrum Analysis/*methods Volatile Organic Compou;"
Notes:		"MedlineArasaradnam, R P Ouaret, N Thomas, M G Gold, P Quraishi, M N Nwokolo, C U Bardhan, K D Covington, J A eng Research Support, Non-U.S. Gov't England 2012/07/07 J Med Eng Technol. 2012 Oct; 36(7):333-7. doi: 10.3109/03091902.2012.690015. Epub 2012 Jul 5"