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Front Physiol

Title:		An Expanded Survey of the Moth PBP/GOBP Clade in Bombyx mori: New Insight into Expression and Functional Roles
Author(s):		Guo X; Xuan N; Liu G; Xie H; Lou Q; Arnaud P; Offmann B; Picimbon JF;
Address:		"Biotechnology Research Center, Shandong Academy of Agricultural Sciences, Jinan, China. Shandong Silkworm Institute, Shandong Academy of Agricultural Sciences, Yantai, China. Protein Engineering and Functionality Unit, UMR CNRS 6286, University of Nantes, Nantes, France. School of Bioengineering, QILU University of Technology, Jinan, China"
Journal Title:		Front Physiol
Year:		2021
Volume:		20211028
Issue:
Page Number:		712593 -
DOI:		10.3389/fphys.2021.712593
ISSN/ISBN:		1664-042X (Print) 1664-042X (Electronic) 1664-042X (Linking)
Abstract:		"We studied the expression profile and ontogeny (from the egg stage through the larval stages and pupal stages, to the elderly adult age) of four OBPs from the silkworm moth Bombyx mori. We first showed that male responsiveness to female sex pheromone in the silkworm moth B. mori does not depend on age variation; whereas the expression of BmorPBP1, BmorPBP2, BmorGOBP1, and BmorGOBP2 varies with age. The expression profile analysis revealed that the studied OBPs are expressed in non-olfactory tissues at different developmental stages. In addition, we tested the effect of insecticide exposure on the expression of the four OBPs studied. Exposure to a toxic macrolide insecticide endectocide molecule (abamectin) led to the modulated expression of all four genes in different tissues. The higher expression of OBPs was detected in metabolic tissues, such as the thorax, gut, and fat body. All these data strongly suggest some alternative functions for these proteins other than olfaction. Finally, we carried out ligand docking studies and reported that PBP1 and GOBP2 have the capacity of binding vitamin K1 and multiple different vitamins"
Keywords:		Lepidoptera abamectin general odorant binding protein insect ontogeny pheromone binding protein silkworm vitamin;
Notes:		"PubMed-not-MEDLINEGuo, Xia Xuan, Ning Liu, Guoxia Xie, Hongyan Lou, Qinian Arnaud, Philippe Offmann, Bernard Picimbon, Jean-Francois eng Switzerland 2021/11/16 Front Physiol. 2021 Oct 28; 12:712593. doi: 10.3389/fphys.2021.712593. eCollection 2021"