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Pharmacol Biochem Behav

Title:		Alarm substance induces convulsions in imipramine-treated rats
Author(s):		Abel EL; Bilitzke PJ; Cotton DB;
Address:		"Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201"
Journal Title:		Pharmacol Biochem Behav
Year:		1992
Volume:		41
Issue:		3
Page Number:		599 - 601
DOI:		10.1016/0091-3057(92)90378-s
ISSN/ISBN:		0091-3057 (Print) 0091-3057 (Linking)
Abstract:		"Male rats were injected with imipramine (0-30 mg/kg) and subsequently tested in the forced-swim test in either fresh water or water soiled by other rats, which presumably contains an alarm substance. Imipramine did not affect the behavior of rats in fresh water. More than half the animals given the combination of imipramine (30 mg/kg) and stress from alarm substance had clonic convulsions. Adrenalectomy did not affect this relationship. This is the first study demonstrating the potential of an alarm substance for inducing convulsions"
Keywords:		"Adrenal Glands/physiology Adrenalectomy Animals Behavior, Animal/physiology Imipramine/*pharmacology Male Pheromones/physiology Rats Rats, Inbred Strains Seizures/*etiology Stress, Physiological/*physiopathology;"
Notes:		"MedlineAbel, E L Bilitzke, P J Cotton, D B eng P50 AA07606/AA/NIAAA NIH HHS/ Research Support, U.S. Gov't, P.H.S. 1992/03/01 Pharmacol Biochem Behav. 1992 Mar; 41(3):599-601. doi: 10.1016/0091-3057(92)90378-s"