| Title: | Analysis of exhaled breath for diagnosing head and neck squamous cell carcinoma: a feasibility study |
| Author(s): | Gruber M; Tisch U; Jeries R; Amal H; Hakim M; Ronen O; Marshak T; Zimmerman D; Israel O; Amiga E; Doweck I; Haick H; |
| Address: | "The Department of Otolaryngology Head and Neck Surgery, Carmel Medical Center, Haifa 34362, Israel. The Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, Haifa 3200003, Israel" |
| ISSN/ISBN: | 1532-1827 (Electronic) 0007-0920 (Print) 0007-0920 (Linking) |
| Abstract: | "BACKGROUND: Squamous cell carcinoma of the head and neck (HNSCC) are wide-spread cancers that often lead to disfigurement and loss of important functions such as speech and ingestion. To date, HNSCC has no adequate method for early detection and screening. METHODS: Exhaled breath samples were collected from 87 volunteers; 62 well-defined breath samples from 22 HNSCC patients (larynx and pharynx), 21 patients with benign tumours (larynx and pharynx) and 19 healthy controls were analysed in a dual approach: (i) chemical analysis using gas chromatography/mass spectrometry (GC-MS) and (ii) breath-print analysis using an array of nanomaterial-based sensors, combined with a statistical algorithm. RESULTS: Gas chromatography/mass spectrometry identified ethanol, 2-propenenitrile and undecane as potential markers for HNSCC and/or benign tumours of the head and neck. The sensor-array-based breath-prints could clearly distinguish HNSCC both from benign tumours and from healthy states. Within the HNSCC group, patients could be classified according to tumour site and stage. CONCLUSIONS: We have demonstrated the feasibility of a breath test for a specific, clinically interesting application: distinguishing HNSCC from tumour-free or benign tumour states, as well as for staging and locating HNSCC. The sensor array used here could form the basis for the development of an urgently needed non-invasive, cost-effective, fast and reliable point-of-care diagnostic/screening tool for HNSCC" |
| Keywords: | "Aged Breath Tests Carcinoma, Squamous Cell/*diagnosis/metabolism Case-Control Studies Diagnosis, Differential Exhalation Feasibility Studies Female Head and Neck Neoplasms/*diagnosis/metabolism Humans Male Middle Aged Sensitivity and Specificity Volatile;" |
| Notes: | "MedlineGruber, M Tisch, U Jeries, R Amal, H Hakim, M Ronen, O Marshak, T Zimmerman, D Israel, O Amiga, E Doweck, I Haick, H eng Research Support, Non-U.S. Gov't England 2014/07/02 Br J Cancer. 2014 Aug 12; 111(4):790-8. doi: 10.1038/bjc.2014.361. Epub 2014 Jul 1" |
