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Psychoneuroendocrinology

Title:		"Behavioral and electrophysiological effects of androstadienone, a human pheromone"
Author(s):		Grosser BI; Monti-Bloch L; Jennings-White C; Berliner DL;
Address:		"Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, USA"
Journal Title:		Psychoneuroendocrinology
Year:		2000
Volume:		25
Issue:		3
Page Number:		289 - 299
DOI:		10.1016/s0306-4530(99)00056-6
ISSN/ISBN:		0306-4530 (Print) 0306-4530 (Linking)
Abstract:		"Androstadienone is the most prominent androstene present on male human axillary hair and on the male axillary skin surface. We have previously shown that this volatile steroid is able to stimulate [corrected] the human female vomeronasal organ in picogram (pg) quantities, resulting in changes in autonomic activity. These effects are gender-specific. The purpose of the present study was to ascertain whether androstadienone could be considered a human pheromone by altering behavior as well as autonomic function. Forty normal female subjects were randomized in a double-blind manner to receive either control or 100 pg of androstadienone directly to the vomeronasal organ. We report that administration of this steroid under these conditions results in a significant reduction of nervousness, tension and other negative feeling states. Concordant changes were observed in autonomic physiology"
Keywords:		Adult Affect/drug effects Analysis of Variance Androstadienes/administration & dosage/*pharmacology Behavior/*drug effects Body Temperature/drug effects Cerebral Cortex/drug effects/physiology Double-Blind Method Electrocardiography Electroencephalography;
Notes:		"MedlineGrosser, B I Monti-Bloch, L Jennings-White, C Berliner, D L eng Clinical Trial Randomized Controlled Trial England 2000/03/29 Psychoneuroendocrinology. 2000 Apr; 25(3):289-99. doi: 10.1016/s0306-4530(99)00056-6"