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J Chromatogr A

Title:		Bridging the gap between gas and liquid chromatography
Author(s):		Gritti F; Fogwill M; Gilar M; Jarrell JA;
Address:		"Waters Corporation, Instrument/Core Research/Fundamental, Milford, MA 01757, USA. Electronic address: Fabrice_Gritti@waters.com. Waters Corporation, Instrument/Core Research/Fundamental, Milford, MA 01757, USA"
Journal Title:		J Chromatogr A
Year:		2016
Volume:		20161018
Issue:
Page Number:		107 - 116
DOI:		10.1016/j.chroma.2016.10.038
ISSN/ISBN:		1873-3778 (Electronic) 0021-9673 (Linking)
Abstract:		"The rapid and complete baseline separation of both volatile (C(5) to C(16) alkanes in gasoline or terpenes in plant extracts) and non-volatile (>C(20) alkanes) organic compounds was achieved by combining (1) low-density fluid chromatography (LDFC) using carbon dioxide at elevated temperature (>90 degrees C) and low pressure (1500psi) designed to increase the retention of the most volatile compounds and (2) high-vacuum technology (<10(-4)Torr) in order to preserve the maximum efficiency of short analytical columns (3.0mmx150mm packed with 1.8mum fully porous HSS-SB-C(18) particles) when used in LDFC. The volatile compounds are eluted first under isobaric conditions (1500psi) in less than a minute followed by a linear gradient of the column back pressure (from 1500 to 3500psi in 5min) for the elution of the non-volatile compounds up to C(40). The experimental results demonstrate that LDFC performed with short 3.0mm i.d. columns packed with sub-2mum particles and placed under adiabatic conditions enables the analysts to deliver a single, fast, and high-resolution separation of both volatile and non-volatile compounds"
Keywords:		"Alkanes/chemistry/*isolation & purification Cannabis/chemistry Carbon Dioxide/chemistry Chromatography, Liquid/*methods Gases/chemistry/*isolation & purification Gasoline/analysis Plant Extracts/chemistry Porosity Pressure Temperature Terpenes/chemistry/*;"
Notes:		"MedlineGritti, Fabrice Fogwill, Michael Gilar, Martin Jarrell, Joseph A eng Netherlands 2016/10/25 J Chromatogr A. 2016 Nov 11; 1472:107-116. doi: 10.1016/j.chroma.2016.10.038. Epub 2016 Oct 18"