| Title: | Odours of cancerous mouse congeners: detection and attractiveness |
| Author(s): | Gouzerh F; Buatois B; Herve MR; Mancini M; Maraver A; Dormont L; Thomas F; Ganem G; |
| Address: | "Centre de Recherches Ecologiques et Evolutives sur le Cancer, Maladies Infectieuses et Vecteurs: Ecologie, Genetique, Evolution et Controle, UMR IRD 224-CNRS 5290-Universite de Montpellier, 34394, Montpellier, France. Centre d'ecologie Fonctionnelle et Evolutive, Universite de Montpellier, CNRS, EPHE, IRD, Universite Paul Valery Montpellier 3, 34293, Montpellier, France. Institut de Genetique Environnement et Protection des Plantes, INRAE, Institut Agro, Universite de Rennes, 35000, Rennes, France. Institut de Recherche en Cancerologie de Montpellier, Inserm U1194-ICM-Universite de Montpellier, 34298, Montpellier, France. Institut des Sciences de l'Evolution, Universite de Montpellier, CNRS, IRD, 34095, Montpellier, France" |
| ISSN/ISBN: | 2046-6390 (Electronic) 2046-6390 (Linking) |
| Abstract: | "Chemical communication plays a major role in social interactions. Cancer, by inducing changes in body odours, may alter interactions between individuals. In the framework of research targeting non-invasive methods to detect early stages of cancer development, this study asked whether untrained mice could detect odour changes in cancerous congeners. If yes, were they able to detect cancer at an early developmental stage? Did it influence female preference? Did variations in volatile organic components of the odour source paralleled mice behavioural responses? We used transgenic mice strains developing or not lung cancer upon antibiotic ingestion. We sampled soiled bedding of cancerous mice (CC) and not cancerous mice (NC), at three experimental conditions: before (T0), early stage (T2) and late stage (T12) of cancer development. Habituation/generalisation and two-way preference tests were performed where soiled beddings of CC and NC mice were presented to wild-derived mice. The composition and relative concentration of volatile organic components (VOC) in the two stimuli types were analysed. Females did not show directional preference at any of the experimental conditions, suggesting that cancer did not influence their choice behaviour. Males did not discriminate between CC and NC stimuli at T0 but did so at T2 and T12, indicating that wild-derived mice could detect cancer at an early stage of development. Finally, although the VOC bouquet differed between CC and NC it did not seem to parallel the observed behavioural response suggesting that other types of odorant components might be involved in behavioural discrimination between CC and NC mice" |
| Keywords: | Animals Female Male Mice *Neoplasms/diagnosis/etiology Odorants *Volatile Organic Compounds Mus musculus domesticus Body odours EGFR oncogenic mutation Female preference Lung cancer Odour discrimination Volatile organic compounds; |
| Notes: | "MedlineGouzerh, Flora Buatois, Bruno Herve, Maxime R Mancini, Maicol Maraver, Antonio Dormont, Laurent Thomas, Frederic Ganem, Guila eng Research Support, Non-U.S. Gov't England 2022/04/12 Biol Open. 2022 Apr 15; 11(4):bio059208. doi: 10.1242/bio.059208. Epub 2022 Apr 29" |
