| Title: | Eco-Metabolomics Applied to the Chemical Ecology of Poison Frogs (Dendrobatoidea) |
| Address: | "Department of Chemistry, Universidad de los Andes, 4976, Bogota, AA, Colombia. mabelg@stanford.edu. Department of Biology, Stanford University, Palo Alto, CA, 94305, USA. mabelg@stanford.edu. Department of Chemistry, Universidad de los Andes, 4976, Bogota, AA, Colombia. c.carazzone@uniandes.edu.co" |
| DOI: | 10.1007/s10886-023-01443-0 |
| ISSN/ISBN: | 1573-1561 (Electronic) 0098-0331 (Linking) |
| Abstract: | "Amphibians are one of the most remarkable sources of unique natural products. Biogenic amines, peptides, bufodienolides, alkaloids, and volatile organic compounds have been characterized in different species. The superfamily Dendrobatoidea represents one of the most enigmatic cases of study in chemical ecology because their skin secretome is composed by a complex mixture (i.e. cocktail) of highly lethal and noxious unique alkaloid structures. While chemical defences from dendrobatoids (families Dendrobatidae and Aromobatidae) have been investigated employing ecological, behavioral, phylogenetic and evolutionary perspectives, studies about the analytical techniques needed to perform the chemical characterization have been neglected for many years. Therefore, our aim is to summarize the current methods applied for the characterization of chemical profiles in dendrobatoids and to illustrate innovative Eco-metabolomics strategies that could be translated to this study model. This approach could be extended to natural products other than alkaloids and implemented for the chemical analysis of different species of dendrobatoids employing both low- and high-resolution mass spectrometers. Here, we overview important biological features to be considered, procedures that could be applied to perform the chemical characterization, steps and tools to perform an Eco-metabolomic analysis, and a final discussion about future perspectives" |
| Keywords: | Alkaloids Amphibian Chemical defences Chromatography Dendrobatoid Mass spectrometry Metabolomics; |
| Notes: | "PublisherGonzalez, Mabel Carazzone, Chiara eng Announcement No. 757-2016 Doctorados Nacionales/Ministerio Administrativo de Ciencia, Tecnologia e Innovacion (MINCIENCIAS)/ Project contract No. 44842-058-2018/Ministerio Administrativo de Ciencia, Tecnologia e Innovacion (MINCIENCIAS)/ Forgivable loan for M.G./Faculty of Science at Universidad de los Andes/ Seed projects INV-2018-33-1259, INV-2019-67-1747/Faculty of Science at Universidad de los Andes/ Doctorados Nacionales 2019/Fulbright Colombia/ Review 2023/08/18 J Chem Ecol. 2023 Aug 18. doi: 10.1007/s10886-023-01443-0" |
